The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling
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Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. In this review, we focus on the regulatory mechanism of ectodomain shedding by ADAM10/17 metalloprotease via GPCR signaling. PAR2 and NK1R induce membrane blebbing, resulting in phosphatidylserine externalization in the cellular membrane, which is required for ADAM10/17 metalloprotease activation.
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The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling
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The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling
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Frontiers Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A
![](https://www.frontiersin.org/files/Articles/736735/fcell-09-736735-HTML/image_m/fcell-09-736735-g001.jpg)
Frontiers Modulation of Microenvironment Signals by Proteolytic Shedding of Cell Surface Extracellular Matrix Receptors
![](https://www.ncbi.nlm.nih.gov/sites/books/NBK285554/bin/tyd-ontogeny-phsyio_figure14.jpg)
Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid - Endotext - NCBI Bookshelf
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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
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The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling
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Antioxidants, Free Full-Text
![](https://www.researchgate.net/publication/377189924/figure/fig1/AS:11431281216069316@1704543279254/Different-mechanisms-of-soluble-receptor-generation-a-Ectodomain-shedding-of-a_Q320.jpg)
Different mechanisms of soluble receptor generation. a Ectodomain
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Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments
![](https://www.scientificarchives.com/admin/assets/uploaded_files/3068251c907700b54eb9a52e88bd8fa680e92985.png)
New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain
![](https://ars.els-cdn.com/content/image/1-s2.0-S1043466620301964-gr2.jpg)
TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P - ScienceDirect
![](https://www.researchgate.net/profile/Custodia-Garcia-Jimenez/publication/5953476/figure/fig2/AS:601587252727841@1520440986983/Structure-of-the-TSHR-protein-The-ectodomain-N-terminus-appears-outside-the-membrane_Q320.jpg)
Structure of the TSHR protein: The ectodomain (N-terminus) appears
![](https://www.scientificarchives.com/admin/assets/uploaded_files/cfb9a15427178e84eac960c4e1e890ec5d58e963.png)
The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling
![](https://europepmc.org/articles/PMC9473748/bin/nihms-1791978-f0001.jpg)
SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo. - Abstract - Europe PMC